Skincare ingredients A–Z

Source: Natural (plant extract)

Artichokes are super rich in antioxidants, which improve skin health and appearance and slow down skin ageing. They are also rich in vitamin C,
which is one of the biggest contributors to healthy collagen development and artichokes aid detoxification. The antioxidants in artichokes also
prevent oxidative stress, which affects skin health. The leaf extract also contains another important chemical called cynaropicrin, which reduces
the damage caused by UV rays and protects the skin. For the treatment of fat, artichoke is a naturally diuretic plant. Indeed, it promotes the renal
elimination of water and the drainage of water retained in the tissues. Thus, the artichoke is excellent for fighting cellulite.

Found in: F-ARTICHOKE, F-XBC, F-MAGISTRAL

Source: Natural (plant-derived)

Arbutin is a widely used ingredient known to help even out skin tone, derived from hydroquinone. It is all-natural and can be extracted from bearberry, cranberry,
blueberry, and pears. Arbutin is widely used to help reduce the appearance of hyperpigmentation, with research pointing to its effectiveness in helping reduce the look of excess melanin. Aside from helping even out skin tone, arbutin also has antioxidant properties that improve skin texture. It’s also used in anti-ageing products because of these characteristics.

Found in: F-MELACLEAR

Source: Synthesis (from fermented L-glutamine)

It is a non-essential and conditionally essential amino acid, meaning the body can usually synthesize sufficient amounts of it, but in some
instances of stress, the body’s demand for glutamine increases, and glutamine must be obtained from the diet. In blood, glutamine is the most
abundant free amino acid. Glutamine helps skin cells function optimally for smooth, radiant, healthy-looking skin. Furthermore, glutamine is known to play an important role in the growth of fibroblast cells. Collagen is the protein that gives skin its youthful firmness, and it
makes up 75% of our skin. As we age, the amount of collagen that we naturally produce begins to decline, and therefore, the breakdown of
collagen and exposure of skin to damaging ultraviolet radiation from the sun lead to the formation of wrinkles and sagging skin. Glutamine
helps to reverse these effects of ageing by significantly increasing collagen production within the skin – reversing the effects of ageing, restoring
skin’s natural tone, and smoothing out the texture. Acetyl glutamine is an improved form of glutamine.

Found in: HAIR MEN MIST, LIFT SLEEPING MASK, MESO REPAIR CREAM

Source: Bio-fermentation (produced from bacteria)

At low concentration this brightening peptide is designed to help reduce the appearance of excess melanin and inhibition of melanosome transport and
melanin-generating enzymes tyrosinase, TR-1 and TR-2. This peptide also functions genetically to diminish the melanin-promoting transcription
factor MITF. Ex-vivo and in-vivo testing point to its effectiveness in helping even out the appearance of dark spots. This peptide is widely used in professional practice as a fast-acting spot-correcting active that is well tolerated and stable.

Learn more: Peptides guide  ·  Found in: F-RADIANCE, F-GLOW LIFT, F-MELATRIX

Source: Bio-fermentation (produced from bacteria)

Hexapeptide that enhances aquaporin 3 (AQP3) expression, improving the water flux from the basal layer of the epidermis to the stratum
corneum. Skin hydration is not only preserved but raised with this hexapeptide. Furthermore, it improves the barrier function and increases
collagen I synthesis and keratinocyte proliferation, providing a complete treatment against skin ageing.

Skin not only protects us against the environment but regulates water exchange. Water is essential for the normal functioning of the skin,
especially for the stratum corneum (SC) and skin barrier properties. Mechanisms that control water transport are not fully understood, but there
is a continuous exchange of water between the SC, the living cells in the underlying epidermis and the atmosphere. Aquaporins are integral
membrane proteins involved in water transport through the different tissue layers, acting as water selective pores. AQP3 is the most abundant
aquaglyceroporin in the human epidermis, facilitating the transport of water, glycerol and other small solutes. Therefore, AQP3 improves
transepidermal permeability, increasing water content in the skin surface and helping the barrier function.

This peptide enhances AQP3 expression levels in keratinocytes, which are inherently reduced due to chronologic ageing and photoageing. In
addition, this peptide presents further properties that contribute to maintaining skin barrier integrity and a youthful appearance.

Learn more: Peptides guide  ·  Found in: F-HYDRALIX

Source: Bio-fermentation (produced from bacteria)

Hexapeptide that increases fatty tissue volume in specific areas improving facial appearance and providing attractive body curves. This peptide
stimulates peroxisome proliferator-activated receptor gamma coactivator 1α (PGC-1α) expression, enhancing adipogenesis rate. This leads to a
higher lipid accumulation and volume growth in the desired areas like lips.
When ageing, skin gets thinner, loses firmness and gravity pulls it downwards leading to undesired and visible changes in the face and body.
Furthermore, adipose tissue, which is mostly found beneath the skin and acting as a supporting tissue, gets redistributed and decreases in areas
like cheeks, facial oval, breasts or lips. Nowadays, the relevance of perfect lips makes people look for efficient and non-aggressive ways of
increasing tissue volume. PGC-1α is a transcriptional coactivator that, interacting with the peroxisome proliferator-activated receptor PPARγ,
modulates adipogenesis rate. This peptide increases local volume improving facial appearance, by promoting PGC-1α expression and lipid
accumulation in the adipose tissue.

Learn more: Peptides guide  ·  Found in: F-PERFECT LIPS

Source: Bio-fermentation (produced from bacteria) & natural (red clover extract)

The importance of hair in our lives cannot be overstated. Whether men or women lose their hair, they lose much more than their natural, youthful
appearance. People also lose their self-esteem and self-confidence associated with healthy looking hair. Hair loss, also called alopecia, is a
common problem affecting both men and women.
Acetyl tetrapeptide-3 is an innovative and unique active complex designed to help support scalp health and encourage the look of hair growth.
It is a biomimetic peptide (acetyl tetrapeptide-3) combined with a red clover extract rich in Biochanin A. The efficacy is based on the combined
and synergistic action of its two ingredients.
Normal hair follicle is surrounded by healthy connective tissue and dermal papilla, and has minimal or absence of inflammation or oxidative
stress. Hair loss sufferers will most of the time have the hair growth cycle disrupted by an increase of dihydrotestosterone (DHT) hormone, loss
of connective tissue integrity surrounding the hair follicle, and an increase of the inflammatory process and oxidative stress in the scalp. With
age, the decreasing number and size of hair follicles in the scalp will also lead to thinner hair and an increase in hair loss.
Acetyl tetrapeptide-3 has a direct action on 5-α-reductase which modulates dihydrotestosterone (DHT) to prevent hair miniaturization. It
improves ECM proteins integrity in dermal papilla for a better hair anchoring. Acetyl tetrapeptide-3 also has a soothing action on the skin, supporting the hair growth process.

• Has a soothing action on the skin, with a synergistic effect compared to red clover extract alone.
• Biochanin A inhibits 5-α-reductase activity, thus confirming its effect on DHT production to help support scalp health in cases of androgenic hair thinning.
• Acetyl tetrapeptide-3 stimulates collagen production for better ECM integrity leading to a better hair follicle anchoring.
• Acetyl tetrapeptide-3 stimulates dermal papilla extracellular matrix proteins, and thus has a direct effect on hair follicle size and anchoring.
• Acetyl tetrapeptide-3 is designed to help stimulate the hair growth process.
Efficacy overview:
• Is designed to help increase anagen hair density, supporting its hair growth stimulating action.
• Is designed to help reduce telogen hair density, which is designed to support a reduction in the hair loss
process.

Learn more: Peptides guide  ·  Found in: HAIR MEN MIST, F-HAIR MEN

Source: Bio-fermentation (produced from bacteria)

As skin loses its elasticity and muscles weaken through age, loose skin can accumulate around the eyes, forming eyebags. Water accumulation
is another reason for puffy eyes, also known as eyelid oedema. This accumulation is due to several vascular diseases, such as a poor lymphatic
circulation or an increased capillary permeability. This peptide fights against oedema-forming mechanisms and shows a decongesting effect,
enhancing elasticity and skin smoothness.

This peptide promotes the inhibition of glycation, which causes tissue damage, and reduces vascular permeability that can help minimize
liquid-related eye puffiness. The ingredient is also efficient in decreasing lipid accumulation, suggesting a potential effect in minimizing eye bags
caused by excess fat. Anti-dark circle effect is also achieved from the peptide due to its ability to degrade the colored bilirubin compound.

• Prevents collagen cross-linking: Inhibition of collagen glycation avoids losing elasticity and subsequent eye bags formation.
• Draining and anti-oedema effect prevents liquid accumulation in eye bags.
• Decrease of dark circles under the eyes: ITA and L* values significantly increased, indicating a slight visible improvement in the appearance of dark circles.

Learn more: Peptides guide  ·  Found in: F-EYE GLOW, F-EYE CONTOUR

Source: Natural

Biorevitalization is a non-surgical procedure used to fight skin ageing and various skin problems in aesthetic medicine.
This ionic balancing formula has 60 ingredients to repair the skin layers. Revitalisation actively repairs the skin to replace minerals that are
deficient such as Magnesium, Sodium, Potassium and Calcium. There are 12 vitamins inside, Vitamins A, B, C and E are just a few that contribute
to skin cell stimulation. Alongside this, there are also 23 different amino acids that help produce elastin and collagen, two significant proteins
making up the skin layers. To combat free radicals, there are also 2 anti-oxidants to ensure your skin remains healthy and glowing.
Revitalisation stimulates production of skin cells so that the added nutrients and vitamins can work in optimum conditions under the skin. It also
stimulates human tissue growth.
The coenzymes catalyze bio-chemical reactions in your client’s skin cells while nucleic acid bases improve cellular communication and vitamins
stimulate vital cell functions, all helping to repair and promote the growth of healthy skin cells. Collagen and elastin are vital for restoring
structure to slack skin, and the amino acids encourage their production along with other important proteins. Minerals to prevent and repair skin
deficiencies and anti-oxidants to protect the skin from free radicals. Provides the essential nutrients to restore and maintain healthy skin.
23 amino acids: Alanine, Arginine, Asparagine, Aspartic Acid, Cystine, Glutamine, Glutamic Acid, Glycine, Histidine, Hydroxyproline, Isoleucine,
Leucine, Lysine, Methionine, Ornithine, Phenylalanine, Proline, Serine, Taurine, Threonine, Tryptophan, Tyrosine, and Valine.
18 vitamins: Ascorbic Acid, Biotin, Choline, Panthenol, Folic Acid, Inositol, Niacinamide, Nicotinic acid (Niacin), Para-Aminobenzoic Acid,
Pyridoxal hydrochloride, Pyridoxine, Riboflavin, Thiamine, Tocopherol, Vitamin A (acetate), Vitamin B12, Menadione (Vitamin K3), Vitamin D2
(Calciferol).
4 minerals: Calcium, Potassium, Magnesium, Sodium.
6 coenzymes: Cocarboxylase (TPP), Coenzyme A (CoA), Flavin Adenine Dinucleotide (FAD), Nicotinamide Adenine Dinucleotide (NAD),
Nicotinamide Adenine Dinucleotide Phosphate (NADP), and Uridine Triphosphate (UTP);
5 nucleic acids: Deoxyadenosine, Deoxycytidine, Deoxyguanosine, Deoxythymidine, and Methylcytosin.
2 reducing agents: Ascorbic Acid and Glutathione.

Learn more: Amino acids guide  ·  Found in: F-XFC, F-XFC+, F-SLIM LIFT

Source: Natural

Caffeine is a strong antioxidant known for its anti-ageing benefits. Caffeine constricts the blood vessels and has a soothing effect, helping reduce the appearance of
puffiness. It also tightens and brightens the skin, visibly reducing the appearance of wrinkles and smoothing away the look of cellulite on the body. Caffeine is able to stimulate
cell metabolism and specifically promotes the hydrolysis of triglycerides into free fatty acids and glycerol, thus reducing adipose storages. It has
also a diuretic effect, which helps to control the liquid retention associated with cellulite.

Found in: F-SLIM LIFT, F-XBC, F-ARTICHOKE

Source: Natural (mineral)

Deficiency of key nutrients, especially calcium, will cause imbalance in our body which in turn affects hair health. Although it is essential to note
the advantages of calcium for hair, yet knowing the consequences of a lack in calcium is equally important. Calcium also helps with the contraction and relaxation of muscles, nerve signaling, blood clotting and with the secretion of hormones and enzymes. Hormones such as androgens
stimulate hair growth; enzymes such as biotin promote cell growth and strengthen healthy growing hair & skin.

Found in: HAIR MEN MIST, HAIR MIST, F-BTX

Source: Synthesis

Carcinine is a nature-identical compound obtained from the decarboxylation of carnosine. Carcinine has demonstrated its ability to protect the
skin integrity from oxidative stress (by detoxification, scavenging and damage repairing). Besides intrinsic ageing, the skin is under the constant
aggression of oxidative entities (solar radiations, pollution, physical stress, etc.). The resulting oxidative stress can affect the structure of the
cutaneous tissue and the metabolic activity of its composing cells such as fibroblasts and keratinocytes. Since these factors are essential for the
quality of the skin, it is a peptidic compound which is able to protect the skin components such as the collagen from these aggressions and to
maintain the metabolic activities of the exposed cells.
Treatment will both prevent and repair the daily aggression-induced damage, allowing the skin to remain healthy, firm and beautiful. It acts in
three different, non-exclusive, ways for a maximal efficiency:
1) Anti-oxidation / anti-stress
2) Anti-glycation
3) Metabolism stimulation

For anti-glycation: protects the collagen and other proteins from the glycation processes at two different levels:
• Prevention: by glucose scavenging.
• Reparation: by substituting itself to the collagen in a transglycation process.

Hence, it prevents the protein from cross-linking, while other anti-oxidants such as vitamin E fail at it. Even more potent than aminoguanidine, a
reference in anti-glycation. Furthermore, the final products of the reaction are neither toxic nor mutagenic. The skin preserves its structure and
elasticity.

A unique anti-oxidant: UV radiation can induce damage that can be monitored by measuring the cell’s redox status. The skin can slowly recover
by itself from UV irradiation. However, even after 24h, the self-healing process still was not complete. Treatment with carcinine led to a full
recovery in just about 8h. It provides a fast and reliable protection against oxidative stress-induced damage as demonstrated. Reduces the
noxious LOOH (lipid peroxide) into harmless alcohol LOH, preventing the protein degradation into toxic free radicals as assessed by HPLC. This
anti-oxidative effect is unique and is not shared by other anti-oxidants such as Vitamin E. Carcinine’s anti-oxidative properties are also due to its
scavenging power as shown by its ability to reduce MDA (a toxic by-product of oxidative stress) production.

Soothing action on the skin: Aggressions can lead to skin irritation. When applied on human reconstituted epidermis, it reduces the secretion of pro-inflammatory cytokines such as TNF-alpha, IL-1 alpha and IL-8. Hence, it has a soothing action on the skin, comparable to that of corticoids but without the associated side effects.

Energizes the skin: Sirtuins are proteins involved in ageing, stress resistance and cell metabolism through their ability to maintain ATP levels. It
stimulates the production of sirtuins in a dose-dependent manner, hence enhancing skin cells metabolic abilities.

Stimulates collagen production: With age, the collagen production is reduced, the firmness of the skin is reduced, wrinkles appear. It stimulates
fibroblastic collagen production in a dose-dependent manner. The skin is denser and younger.

Improves hair density: By increasing the amount of hair in the anagen phase, this treatment, when coupled with organic silica, is designed to help improve hair density for men experiencing hair thinning. The hair looks denser and healthier.

Found in: F-LIFT+ FACE

Source: Natural, extracted from centella asiatica leaves.

Centella asiatica was first valued in pharmaceutical applications for its reparation properties. Cica extract is highly purified in triterpene
molecules, for its restorative properties on cosmetic and dermo-cosmetic applications. Cica accelerates skin repair process on damaged skin
and acts on the restoration of its integrity. Our cica extract is produced from centella asiatica leaves harvested in Madagascar. The extract is
highly purified to reach the highest concentrations in Asiaticoside, Madecassic Acid and Asiatic Acid. Centella asiatica is also referred to as “tiger
grass” or “tiger herb”.

Cica works to repair damaged skin and restore skin integrity: by boosting the vital proteins within the dermis, by soothing effect.
The interest of Cica in skincare and for post medical procedures is of high interest. Faster repair of damaged skin, skin remodeling, redensifying,
anti-stretchmarks. Products can be used to repair the skin faster after laser, peelings, meso-needling and many other treatments where the skin
integrity is damaged.

Cica is widely used in professional practice to support skin repair after laser treatment, helping improve dermis density and soothe the skin more quickly than without treatment.

Found in: CICA POST-CARE, F-MESOMATRIX, F-XBC

Source: Natural (mineral)

Copper is commonly used in food, cosmetics and other fields. It can be used to treat medical conditions like copper deficiency that often leads
to anemia. It also has antioxidant and soothing properties, helping cellular regeneration, restoring skin vitality and immunomodulatory
function, delaying senescence.

Found in: HAIR MEN MIST, HAIR MIST, F-HA LIFT

Source: Bio-fermentation (produced from bacteria)

Copper Peptide is a naturally occurring human tripeptide. In plasma, the level of Copper peptide is about 200 ng/ml at age 20. By the age of
60, the level drops to 80 ng/ml. Copper peptide is known to support a range of biological actions such as activation of wound healing, attraction of immune cells, antioxidant and soothing effects, and stimulation of
collagen etc. It is widely used as a reparative and anti-ageing ingredient but it also helps enlarge hair follicles and stimulate hair growth.

Learn more: Copper peptides guide  ·  Found in: F-HA LIFT

Source: Natural (plant-derived)

Coumarins are a large group of substances, primarily of plant origin. Like their more intensively examined congeners flavonoids, many of them
are antioxidants. Coumarins exhibit direct effects on the cardiovascular system which are not based on antioxidant activity. Moreover, coumarins
have been shown to possess antiplatelet and vasodilatory potential. Interestingly, the former effect may be mediated by the inhibition of various
pathways leading to platelet aggregation, their differing effects on those pathways being due to structural differences between the various
coumarins.

Found in: F-XBC, F-MAGISTRAL

Source: Synthesis

DMAE is an abbreviated term for an antioxidant membrane stabilizer called dimethylaminoethanol. DMAE strengthens skin cells and their
membranes and in doing so protects the cells’ structure from damaging free radicals. Also it helps to defy the effects of muscular sagging. DMAE
helps to tighten skin and reduce the appearance of sagging, improve firmness and elasticity, smooth the appearance of fine lines and wrinkles, and brighten the skin.

Found in: F-DMAE, F-XFC+ FACE, F-SLIM LIFT

Source: Bio-fermentation (produced from bacteria)

Oligopeptide-24. CG-EDP3 acts as an anti-wrinkle, skin lifting and firming agent. It is a double layered encapsulated biomimetic peptide which helps reduce the appearance of lines and wrinkles by actively generating new skin cells. It enhances skin tone that brims with vitality and energy and
helps reduce the appearance of scars on skin by forming new skin cells. Exhibits up-regulation of cell growth and migration, cell survival, extracellular matrix expression.

Learn more: Peptides guide

Source: Bio-fermentation (produced from bacteria)

EGF is produced by modern bioengineering method-fermentation, using glucose as raw material. It has the same molecular structure and
biological activity as EGF secreted naturally by human body. It can promote the epidermis cell growth, thus can be applied in anti-wrinkle and
anti-ageing. In addition, it can also brighten the skin and help reduce the appearance of wrinkles. EGF participates in skin regeneration through stimulation, proliferation
and migration of keratinocyte, endothelial cells and fibroblasts.

Learn more: Growth factors guide  ·  Found in: HAIR MEN MIST, ACURHYAL Stim, F-XFC+

Source: Synthesis

Et-Vitamin C is a multi-functional vitamin C derivative with excellent brightening, antioxidant, free radical-scavenging and collagen boosting
effect. Its stability is superior to other ascorbic acid derivatives. It exhibits strong inhibition effect on melanogenesis, helps reduce the appearance of dark spots and age spots, helps address photoageing by interfering with inflammatory cytokines and reverses ROS production to achieve free radical scavenging
purpose.

Found in: VITAMIN C 5.0, VIT C MICRO-WATER

Source: Bio-fermentation (produced from bacteria)

Gently eliminates the dead cells to reveal younger, healthier looking skin. An enzymatic exfoliation based on a protease obtained by
fermentation. Enzymatic action that eliminates dead skin cells to smooth the skin’s surface and promote cell renewal. A gentle, enzymatic
alternative to AHAs.

Source: Bio-fermentation (produced from Lactobacillus bacteria)

Lactobacillus exosomes are nano-sized vesicles derived from Lactobacillus bacteria, often associated with probiotic strains beneficial to human health. In skincare, these exosomes have gained attention for their potential to support and enhance skin health. Exosomes are tiny, membrane-bound vesicles that carry proteins, lipids, and RNA from the parent cell, and in the case of Lactobacillus, they transport beneficial components derived from the bacteria that can influence skin biology.

1. Enhanced Skin Barrier Function: Lactobacillus exosomes can help strengthen the skin’s natural barrier. They promote the formation of tight junction proteins, which are crucial for keeping skin cells closely bonded and preventing moisture loss. This can lead to improved hydration and a stronger defense against environmental pollutants and pathogens.

2. Soothing Effects: These exosomes can help calm the skin by modulating immune responses. They may help reduce the appearance of redness, soothe irritation, and support the appearance of skin prone to acne or rosacea by curbing the activity of inflammatory cytokines.

3. Antioxidant Properties: Lactobacillus exosomes may have antioxidant properties, which help neutralize free radicals and reduce oxidative stress on the skin. This is beneficial for slowing down the visible signs of ageing, such as wrinkles and fine lines.

4. Promotion of Skin Microbiome Health: Exosomes from Lactobacillus bacteria help maintain a healthy balance in the skin microbiome. A balanced microbiome can improve overall skin health, reduce the risk of infection, and support the natural protective functions of the skin.

5. Cell Regeneration and Repair: These exosomes are known to help promote skin cell proliferation and migration, which aids in wound healing and the repair of damaged tissue.

6. Brightening and Even Skin Tone: By modulating the skin’s immune response and enhancing cell turnover, Lactobacillus exosomes can help achieve a brighter, more even-looking skin tone, helping reduce the appearance of hyperpigmentation.

Learn more: Exosomes guide  ·  Found in: F-EXOSOMES, EXOSOMES SERUM, EYE BOOSTER

Source: Bio-fermentation (produced from bacteria)

FGF is produced by modern bioengineering method-fermentation, using glucose as raw material. It has the same molecular structure and
biological activity as FGF secreted naturally by human body.
FGF (basic and acidic forms) stimulate the growth and mitogenesis of fibroblast cells. FGF participates in skin regeneration by increasing the
production of collagen and elastin in fibroblast cells. Basic FGF (FGF-2) in particular activates also the synthesis of hyaluronic acid.

Learn more: Growth factors guide  ·  Found in: HAIR MEN MIST, F-XFC+, F-LIFT+ FACE

Source: Natural (plant extract)

In the Far East, the ginkgo is known for its remarkable longevity, it seems that it can live up to 4,000 years. It is the only tree that survived
Hiroshima in 1945. Its active constituents are flavonglycosides (Ginkgolide heterosides), quercetin, proanthocyanidins, lactones and terpenes.
Anti-ageing. Photoprotection. Hair color protection. Re-epithelizing. Anti-irritation. Blood circulation stimulation. Decongestant. Anti-cellulite.
Ginkgo leaf extract contains quercetin and kaempferol, natural plant flavonoids that act as antioxidants, and help fight free radicals. These components may result in soothing and anti-ageing effects. Ginkgo contains a powerful inhibitor of tyrosinase, which is an enzyme
responsible for the development of pigment in the skin. Hence, ginkgo extracts, when applied to the skin, may help even out skin tone. This is particularly desirable for consumers who wish to help reduce the appearance of pigmentation and age spots, and maintain a brighter-looking skin tone. Microcirculatory
effects (the ability to dilate and increase blood flow in small blood vessels). Studies have shown the ability of ginkgo to enhance blood flow in
the skin. Increased blood flow may help speed up skin healing. This may also result in a local synergistic effect, whereby the availability and
impact of other ingredients in the area where it is applied is enhanced.

Found in: F-GINKGO, F-COUPERIX, F-XBC

Source: Bio-fermentation (from glucose)

Gluconolactone is a lactone compound formed by removing one molecule of water from gluconic acid, soluble in water and ethanol, mild
without irritation. It penetrates cells slowly because of its large molecular weight, so it has better hydrating properties compared with hydroxyl
acid (AHA) and is suitable for sensitive skin. In addition, it also has antioxidant and soothing properties, improving skin luster and
making the skin tone even. Gluconolactone is widely used in formulas for oily skin and skin prone to acne or rosacea.

Found in: HYALURONIC PEEL, RADIANCE CREAM

Source: Bio-fermentation (produced by yeast fermentation)

Glutathione plays an important role in cell protection during ageing, acting both as anti-oxidant and detoxifying agent. It has very good ability to inhibit melanin synthesis, making it a valued ingredient in formulas for skin prone to melasma and for helping reduce the appearance of pigmentation. It is binding itself to toxins such
as heavy metals, chemical pollutants and carcinogens and transforming them into a form which can be easily flushed out of the body. It is a
powerful antioxidant found within every cell protecting our cells from free radicals.

Found in: ACURHYAL Glow, F-RADIANCE, F-MELACLEAR

Source: Bio-fermentation (produced from bacteria)

Crosslinked polymer derived from naturally sourced Hyaluronic Acid. This active ingredient is commonly used in dermal filler injections. It
appears like an elastic gel with high viscosity able to form invisible biological film on the skin surface with various effects, such as moisturising,
protection and reducing the appearance of wrinkles.

The crosslinked hyaluronic acid micro structure was studied by using scanning electron microscopy to demonstrate that it forms a 3D
“breathable” layer on the surface of the skin that improves the skin barrier function, reduces the water evaporation and prevents the skin damage
caused by external aggressions like UV rays, pollution, etc.

The viscosity of a crosslinked hyaluronic acid solution is 3 times higher compared to conventional hyaluronic acid solution at the same
concentration, which indicates that it can bind more water molecules because of its crosslinked structure. It behaves like a “micro reservoir”
delivering continuously water to the skin.

Crosslinked hyaluronic acid is designed to help increase skin elasticity over time and is widely used in professional practice to help improve the appearance of skin smoothness.

Learn more: Hyaluronic acid guide  ·  Found in: HA DEEP FILLER, MESO LIFT CREAM, EYE SORBET

Source: Bio-fermentation (produced from bacteria)

The study of the mechanisms of skin ageing has traditionally overlooked an important area: the dermo epidermal junction (DEJ). This is the layer
responsible for supporting the epidermis and for the communication between epidermal and dermal cells.

The DEJ is physically a basement membrane that separates the skin cells in the epidermis from the extracellular matrix (ECM) which lies below,
in the dermis. This membrane is composed of two layers, the basal lamina, in contact with the cells, and the underlying reticular lamina, in
contact with the ECM. The basal lamina is rich in collagen type IV, proteoglycans and the glycoproteins entactin and laminin. These molecules
provide a structural network and bioadhesive properties for cell attachment.

Laminin is a glycoprotein of about 850 kDa and it is, after collagen, the most abundant protein in the ECM. However, while Collagen performs
exclusively a structural role in the skin, Laminin is involved in functionalisation and activation of cells, in processes such as cell proliferation,
migration and adhesion. These mechanisms are necessary to keep the normal balance of the skin and are essential for processes as important
as wound healing, for instance.

Laminin only exists in basement membranes. It is composed of three very long polypeptide chains (alpha, beta and gamma) arranged in the
shape of an asymmetric cross and held together by disulfide bonds. The three chains exist as different subtypes which result in twelve different
isoforms for laminin, of which the best well-studied is Laminin-1.

Keratinocytes recognise the binding domains on Laminin, particularly Laminin-5, by using their own integrin receptors, transmembrane proteins
located on specific junction points called hemidesmosomes.

Researchers have identified and synthesized a sequence from the alpha chain of Laminin: hexapeptide-10. This peptide retains many of the
characteristics of the native protein, and promotes cell adhesion and proliferation.

Certain features of the DEJ are altered by the ageing process, such as the anchoring ability of keratinocytes, probably due to deficiencies in the
expression of integrins as we age. Laminin-5 synthesis has also been proved to decrease in aged skin. This causes a loss of contact between
dermis and epidermis, and results in the skin losing elasticity and becoming saggy. The cohesion between dermis and epidermis is essential to
maintain skin balance because it enables the transport of oxygen, nutrients and waste, contributing to the health of the epidermis.

This work will show that a synthetic hexapeptide from Laminin-1 is able to restore the skin’s normal function by promoting synthesis of Laminin-5,
stimulating keratinocyte and fibroblast proliferation, inducing a redensifying effect on the dermis, and an improvement in skin elasticity,
compactness, tonicity and smoothness.

Learn more: Peptides guide  ·  Found in: F-LIFT+ FACE, F-EYE CONTOUR

Source: Bio-fermentation (produced from bacteria)

Hyaluronic Acid is the most hydrated biopolymer known. In living tissues it serves as a connective tissue organizer and water holding substance.
The sodium hyaluronate is coming from a biotechnical safe process; it is free of contaminants and GMO. A certain level of stratum corneum
hydration is essential for skin smoothness and elasticity, as well as for enzyme reactions important for skin renewal and desquamation.
Hyaluronic Acid is forming a film on the skin and so hydrates the topical layers of stratum corneum. In addition this film reduces the irritating
and negative influences of environment to the skin.

Learn more: Hyaluronic acid guide  ·  Found in: F-HA, HA DEEP FILLER, HYALURONIC DROPS

Source: Bio-fermentation (produced from bacteria)

Hyaluronic Acid is the most hydrated biopolymer known. In living tissues it serves as a connective tissue organizer and water holding substance.
The sodium hyaluronate is coming from a biotechnical safe process; it is free of contaminants and GMO. XS Hyaluronic Acid is a very low
molecular weight hyaluronic acid. It is a breakthrough in anti-ageing properties with increased permeation through the skin compared to high
molecular weight hyaluronic acid. It rejuvenates the skin by improving its viscoelastic properties and visibly reduces the appearance of deep wrinkles.

Learn more: Hyaluronic acid guide  ·  Found in: HAIR MEN MIST, HAIR MIST, VITAMIN C 5.0

Source: Bio-fermentation (produced from bacteria)

Decapeptide-4. CG-IDP2 acts as an anti-wrinkle, skin lifting and hair growth promotion active. It is a double layered encapsulated bio-mimetic
peptide which strengthens skin elasticity by inducing the synthesis of collagen and elastin. It is involved in normal skin growth, healing and
wound repairing. It helps reduce the appearance of lines and wrinkles by actively generating new skin cells. Increases the cell density and longevity.

Learn more: Peptides guide

Source: Bio-fermentation (produced from bacteria)

Insulin-like growth factor (IGF-I), one of the body’s many growth factors. Insulin-like growth factors are substances that promote growth in the
muscles. IGF-I regulates the anabolic effects. It goes to the muscles and ligaments where it develops lean tissue. By traveling to the fat cells,
IGF-I burns fat. Subsequently, it increases lean body mass and decreases fat. Increases lean body mass, helping you burn fat, and builds up
physical endurance. It increases protein synthesis, which in turn prompts tissue repair and accelerates skin recovery after aesthetic procedures.
At the dermal level IGF-1 helps to restore the phospholipid profile of the skin; it has a synergic effect with EGF on skin regeneration. IGF-1
increases the synthesis of hyaluronic acid and chondroitin sulfate proteoglycan by fibroblasts.

Learn more: Growth factors guide

Source: Natural (mineral)

Iron helps boost circulation and carries oxygen to your hair’s roots, which helps the hair grow faster and longer. An iron deficiency can lead to
hair loss. Some good sources of iron include clams, beans, lentils, pumpkin seeds, sesame seeds, oysters, grass-fed beef and bison. Iron
contributes to the production of hemoglobin in your body. Hemoglobin delivers nutrients and oxygen to your hair’s cells, which is vital for their
growth. This process is disrupted by a lack of iron, which also means low hemoglobin levels, leading to loss of hair.

Found in: EYE BOOSTER, HAIR MEN MIST, HAIR MIST

Source: Bio-fermentation (produced from bacteria)

Is an alpha hydroxy acid (AHA), a class of chemicals that gently exfoliate the skin. Lactic acid is suitable for those who have easily irritated skin. It
also helps to keep pores clear by sloughing away dead cells plus excess oil, preventing pesky pimples, blackheads or whiteheads from forming.
Lactic acid effectively speeds up cell turnover and stimulates cell renewal; moreover, it helps improve the skin’s natural moisture factor, or the
way the skin keeps itself hydrated. Basically, lactic acid helps to keep the skin moisturised and feeling less dry.

Found in: LIFT SLEEPING MASK, GLOW SLEEPING MASK

Source: Natural

It is an amino acid derived building block (it’s produced in the body naturally) for proteins that assists with the breakdown of fats and lipids. It
helps the body turn fat into energy. L-carnitine is responsible for transporting long-chain fatty acids to the mitochondria, where energy is then
produced as the fat is oxidised and used for fuel. More than 95% of the body’s L-carnitine is found in skeletal muscle (which is connected to
the skeleton), along with trace amounts in the liver and blood.

Found in: F-CARNITINE, F-XBC, F-ARTICHOKE

Source: Natural (mineral)

Magnesium plays a number of roles in the body, being required for more than 325 enzymatic reactions, including those involved in the synthesis
of fat, protein and nucleic acids, neurological activity, muscular contraction and relaxation, cardiac activity and bone metabolism. Helps prevent
calcium buildup on your scalp. When calcium clogs hair follicles, your scalp will be dry, flaky, and you could even see some hair loss. These
calcium deposits on and around the hair follicles can increase over time due to scalp inflammation. Also magnesium helps with protein synthesis.
Since hair follicles are made almost entirely of protein, this is key. Better protein synthesis means healthier hair and a predictable hair cycle with
normal growing and resting stages. Protein synthesis also helps create melanin, which helps prevent your hair from going gray.

Found in: HAIR MEN MIST, HAIR MIST, F-HAIR

Source: Natural (plant extract)

Used to increase the loss of water from the body through the urine (as a diuretic). It is also used for varicose veins and to relieve symptoms of
poor blood circulation (chronic venous insufficiency) including leg pain and heaviness, night cramps, itchiness, and fluid retention (oedema).
Melilotus is sometimes used along with regular medicines for treatment of blood clots in the veins. Other uses include treatment of blockage of
the lymphatic system. The lymphatic system drains fluid from tissues. Some people apply it directly to the skin for bruises.

Source: Bio-fermentation (produced from bacteria)

Muscles beneath the skin precisely control movement of forehead, eyes, nose, lips and mouth in such a way that human face is capable of more
than 10,000 different expressions. Facial expressions are vital as they are a means of communication and convey emotional states. Apart from
having a role in social interaction, they influence perception of attractiveness. An expressive face is beautiful, as it transmits personality and
emotions. But there is a downside, as facial expressions are linked with the formation of expression wrinkles (or mimic wrinkles).
The most effective strategy to reduce the appearance of expression wrinkles and slow their progression over time is to reduce excessive stimulation
of muscle cells.

Molecules that can modulate neuronal exocytosis can contribute to relaxing muscular tension, and therefore they can be used to reduce the
appearance of wrinkles. Botulinum neurotoxins (BoNTs) are naturally-occurring proteins that act through such mechanism of action. This kind of
toxin cleaves the proteins that make up the SNARE complex, blocking neuronal exocytosis at the NMJ in an irreversible manner and paralyzing
muscle contraction as a result.

The injection of BoNTs to the skin avoids the formation of expression wrinkles, but this procedure is not exempt from adverse side effects
including allergic reactions. In addition, due to muscle paralysis, side effects such as drooping eyelid or facial asymmetry and a loss of facial
expressivity can occur. Besides, the anti-wrinkle effect lasts for a limited period of time, typically 3-4 months, requiring regular re-applications.
Biomimetic competitive inhibitory peptides are developed to imitate proteins found in the skin and compete with them to modulate their
functions.

The application of biomimetic peptides that compete with the skin components involved in neurotransmitter exocytosis can lessen the process
of muscle contraction in a reversible and controlled manner, and thus it helps reduce the appearance of expression wrinkles. In addition, these small
compounds can be topically applied and are not associated with adverse effects. Therefore, biomimetic inhibitory peptides are a well-tolerated alternative to neuromodulator injectable treatments and they allow maintaining natural expressions of the face, so important to feel comfortable.

Length of these competitive peptides is critical for their inhibitory activity. Longer peptides usually have a higher similarity with the native
protein, which enhances their affinity and inhibitory capacity. Peptides showing high activity can be applied topically to delay the progression
of expression lines into permanent wrinkles that are deeper and more visible, especially in middle-aged women.

This octapeptide is an elongation of the revolutionary ARGIRELINE® peptide. Because these peptides are patterned after the N-terminal
domain of SNAP-25, they can bind to the SNARE complex causing its destabilization. As a result, vesicles cannot release neurotransmitters as
efficiently in the NMJ, therefore muscle contraction can be attenuated.

The topical application of octapeptide could help to prevent the formation of lines and wrinkles caused by the repetitive contraction of
muscles of facial expression with an alternate mechanism to neuromodulator injectable treatments. This would apply to wrinkles that have already appeared by 30s
or even before, but also to delay their progression through the 40-50s, helping to maintain a smoother skin in those areas prone to show deeper
and more visible wrinkles.

In vitro efficacy tests indicate that octapeptide inhibits the formation of the SNARE complex and that it can also modulate the release of neurotransmitter by neuron cells. It is designed to help visibly reduce the appearance of wrinkle depth and skin roughness after the treatment
application in areas with expression wrinkles.

Learn more: Peptides guide  ·  Found in: F-BTX

Source: Synthesis

Silicium is an essential component of the skin. Indeed, by interacting with structure and elastic proteins within the dermis such as collagen fibers,
elastin and proteoglycans, the silicium ensures optimal skin organization and architecture. Furthermore, many studies show that silicium is
capable of stimulating skin cell metabolism for enhanced cell proliferation and activity (e.g. collagen production, contraction ability…).
However, with age the amount of silicium naturally present in the skin tends to decrease. As a result, an overall collapse of the skin architecture
will happen, which will in turn induce skin metabolism to slow down, inevitably leading to wrinkles.
With the silanol technology, we replenish the natural pool of silicium hence allowing a complete skin restructuration for global benefits at all
levels.

• Within the epidermis, organic silicium or silica improves keratinocyte proliferation. Because of ageing, keratinocytes have a lower proliferation
rate that slowly leads to an epidermis thinning and eventually weakens skin protection and reduces skin hydration because of an increased
transepidermal water loss. Organic silicium improves the number of proliferative keratinocytes in human reconstructed epidermis. That leads to
a thickening of the epidermis for a skin that will be better protected and better hydrated.
• Within the DEJ, organic silicium improves skin cohesion. The dermal epidermal junction (DEJ) is the interface between both skin compartments. It is responsible for skin cohesion. With age, the DEJ becomes thinner and can be duplicated, hence leading to a loss of cohesion and
a decreased cell communication. Organic silicium is capable of improving collagen VII expression, one of the key constituents of the DEJ in
human skin explants. This leads to an improved skin cohesion and skin cell communication.
• Within the dermis, organic silicium improves collagen production. With age, all metabolisms tend to slow down. In the dermis
this results in a lower proliferation rate and a lower activity of fibroblasts. There are too few collagen fibers and the skin is flaccid and wrinkled.
Organic silicium stimulates fibroblast number and activity. In the dermis, there will be more fibroblasts and each one of them will produce
more collagen. This strong collagen booster effect leads to a firmer and more elastic skin, helping reduce the appearance of wrinkles.
• Within the hypodermis, organic silicium improves lipolysis. With age, there are more and more adipocytes (fat storing cells). This causes a fat
accumulation leading for example to cellulite on the body and eye bags on the face. Organic silicium stimulates adipocyte ability to get rid of
the fat by improving lipolysis. A treatment with organic silicium is designed to help increase the amount of fat released by adipocytes, helping visibly reduce the appearance of cellulite for firmer-looking skin and reduced eye bags.

Recognized as a separate entity within the skin, the hair follicle’s formation and maintenance is linked to the interaction between its dermal
and epidermal components. It is in the hair follicles that are located the actively proliferating cells that generate hair. Both the hair quality and
quantity depend on the significant presence of silicium in the dermis, epidermis and the hair shaft. Organic silicium demonstrated a significant
improvement on hair growth and vitality in combination with carcinine.

Found in: HAIR MEN MIST, HAIR MIST, F-XFC+ FACE

Source: Animal

PDRN—polydeoxyribonucleotide, a 50–1,500 kDa, >90 % pure DNA fragment extracted from salmonid sperm—functions as a high-affinity adenosine A2A receptor agonist that elevates intracellular cAMP, has a soothing action on the skin via NF-κB signalling, and simultaneously donates nucleotide building blocks via the salvage pathway to ischemic or UV-damaged fibroblasts, is designed to help accelerate wound closure, support epidermal thickness, up-regulate VEGF and collagen I/III, and reduce IL-6/TNF-α, thereby supporting faster tissue repair, angiogenesis, and visible anti-photoageing effects when injected or topically combined with micro-needling.

Learn more: PDRN guide  ·  Found in: EYE BOOSTER, SKIN BOOSTER CREAM

Source: Bio-fermentation (produced from bacteria)

Expression wrinkles are a particular type linked to repeated muscular contraction and they usually appear as soon as the age of 30. Muscles are
contracted when they receive acetylcholine released from a vesicle in the neuronal exocytosis. In order to fuse a vesicle with the cellular
membrane, two events are required: the SNARE complex formation and the entry of calcium ions into the neuron. Pentapeptide is a modified
enkephalin that couples to the enkephalin receptor, outside of nerve cells. This association releases G protein subunits (α, ß, Y), which close
calcium channels avoiding vesicle fusion and consequently inhibiting acetylcholine release across the synapse. This process maintains the
neuron in its resting state, attenuating muscle contraction and preventing the formation of lines and wrinkles.

Learn more: Peptides guide  ·  Found in: F-BTX

Source: Natural

It’s a plant extract with some antioxidant and soothing effects. Like other antioxidants, phytic acid can help to neutralize free radical
damage in the skin. Moreover, it holds the ability to absorb certain minerals – specific ones that can have detrimental effects on the skin when
they become too abundant. It appears to work mechanically to absorb up iron molecules in the skin, which are responsible for causing damage
to DNA. Phytic acid is a gentle AHA and is great for those with sensitive skin or those with rosacea.

Found in: F-COUPERIX

Source: Bio-fermentation (produced from bacteria)

A pre/probiotic complex, spray dried on maltodextrin, made of:

• α-glucooligosaccharides (GOS), obtained by enzymatic synthesis, from vegetal substrates (corn maltose, beetroot saccharose),
• a pure plant juice, rich in β-fructooligosaccharides (FOS), obtained by cold pressing, of jicama or yacon tubers (Polymnia sonchifolia),
• Lactobacillus probiotic bacteria (L. casei, L. acidophilus), inactivated by tyndallization and freeze-dried. This product is used for the optimization of the cutaneous ecoflora, the strengthening of biological defences, and the improvement of the skin radiance by a restructuring and
smoothing effect.

Found in: PROBIOTIX CREAM

Source: Natural

Pyruvic acid, a product of pyruvate, is a natural compound produced by the body that helps make and use energy. Because it is instrumental
in the metabolism of fat, people sometimes take pyruvate supplements to lose weight. Although studies have indicated that it may be an
effective weight-control supplement.

Scientists believe pyruvate exerts a fat-loss effect in several possible ways: may increase the breakdown of fat in the body; may increase
muscle mass. This has been observed in some research and could also account for pyruvate’s metabolic-stimulating effect, because muscle
increases metabolism; prevents fat regain and helps you keep weight off; works as an antioxidant to fight free radicals and heal the tissue
damage they cause; reverses the order in which the body uses energy. Normally, the body draws on carbs first for energy, then protein, and finally
fat. Remarkably, pyruvate appears to reverse that order to burn fat first for its energy needs. But why the reversal? Pyruvate may reduce
insulin levels in the body. Insulin is a busy hormone. Among its duties is to promote fat storage. But if insulin levels are low, less fat is stored in
fat cells – which could partially explain pyruvate’s effect on fat-burning.

Found in: F-HAIR

Source: Synthesis

Hexylresorcinol is widely used to help reduce the appearance of hyperpigmentation and works by modulating multiple sites in the
melanogenesis pathway. It shows also other surprising functions as it increases levels of glutathione and stimulates the antioxidant defense
enzymes – glutathione peroxidase and glutathione reductase. Glutathione is well known to protect the cells from oxidative injury and DNA
damage. Moreover, it has antibacterial properties which makes it an ingredient of choice for oily skin types.

Found in: F-MELACLEAR, MELA DROPS, RADIANCE CREAM

Source: Natural (plant-derived)

Rutin has the capacity to regenerate vitamin C after it neutralizes a free radical, thus helping to restore its antioxidant potential. Because vitamin
C plays a critical role in the manufacture of collagen, an important component of capillary walls as well as the sustaining framework of the
epidermis, this could have a dramatic impact on the health of your skin. Rutin has the ability to protect skin from damage caused by advanced
glycation end products (AGEs). AGEs accelerate the ageing of skin cells, which cause the skin to lose elasticity and collagen. Research suggests that rutin can help modulate the breakdown of collagen caused by AGEs. Rutin’s ability to provide microvascular protection,
improve circulation, and defend against free radical damage makes it an excellent ingredient in any natural skin care formulation for ageing skin.
Also, because rutin can penetrate the skin, it makes it extremely valuable.

Found in: F-XBC, F-MAGISTRAL

Source: Bio-fermentation (produced by fermentation)

Superoxide dismutase is the most powerful antioxidant enzyme in the body. By protecting the skin from free radical damage, superoxide
dismutase prevents visible signs of ageing. Even better, it helps repair signs of ageing. It does this by promoting a youthful complexion,
encouraging resilient skin. It also helps reduce the appearance of hyperpigmentation from UV damage and age spots.

Source: Synthesis

Taurine is considered one of the most important amino acids; it is used in skin care products, particularly anti-ageing lines, where it is said to help
calm the skin. The primary role of taurine in the human system is as an antioxidant, which is one reason it helps soothe the skin. In skin
care, taurine is a powerful form of anti-fatigue. When applied topically, taurine re-energises skin to minimise the signs of fatigue. It boosts
circulation and inter-cellular energy—helping with rehydration; so your skin instantly looks and feels more awake. And with continued use,
taurine can give you really improved radiance with a renewed glow.

Found in: F-XBC

Source: Bio-fermentation (produced from bacteria)

Rosacea is said to affect 45 million people worldwide. The inflammation of capillaries and pilosebaceous units, erythema, telangiectasia (dilated
capillaries), flushing skin, pustules, itching and Post-inflammatory Hyperpigmentation (PIH) are frequently associated with skin redness
disarrangements. All these effects are mainly located in the central third of the face.
Rosacea

COUPERIX• Chronic skin redness disorder with visible capillaries that can also turn the skin dull.
• It typically affects individuals with pale skin and especially women over 30.
• Its etiology is uncertain but several factors can induce it (strong emotions, spicy food, playing sport, alcohol…).
In the natural response of the immune system to potential harmful agents and conditions, kallikreins and antimicrobial compounds like
cathelicidins have an important role. They induce the release of interleukins (IL), which are among the increased molecules in facial skin redness
and vascular alterations. In skin disorders with erythema and dilated blood vessels, like rosacea, LL-37 expression is found to be abnormally high,
it is locally activated and a cascade of inflammatory reactions leads to an increase of pro-inflammatory metabolites, IL-6 and IL-8 among
others. The dermal connective tissue may be damaged as the proteolytic degradation of the extracellular matrix (ECM), mainly of collagen, is
increased due to Matrix Metalloproteinases (MMPs) activation. Therefore, red areas become more visible as capillaries are fragile and permeable,
and blood vessels can easily dilate due to inflammation. Tetrapeptide helps to decrease facial redness and other skin disorders caused
by LL-37 activation and subsequent release of ILs. It also provides a photoprotective effect, helping to lower cell damage and support the skin’s comfort.
• Tetrapeptide is designed to help lower LL-37-mediated IL-6 and IL-8 release.
• It is designed to help reduce connective tissue degradation by inhibiting collagenase
activity.
• Erythema, redness and extent intensity are reduced by Tetrapeptides.
• Skin roughness is also visibly improved by the end of the treatment.

Learn more: Peptides guide  ·  Found in: HAIR MEN MIST, F-EYE GLOW, F-COUPERIX

Source: Synthesis (lysine derivative)

Traditionally, tranexamic acid is actually a drug which has been used in surgery to stem bleeding; it is also widely used in professional practice to help reduce the appearance of skin prone to melasma and hyperpigmentation. It is well tolerated across a wide range of skin types and skin tones. Tranexamic acid provides a powerful and specific soothing action on the skin, inhibiting tyrosinase synthesis in melanocytes to keratinocytes in the epidermis. Also, it calms the skin and helps to
restore the skin barrier. In fact, tranexamic acid decreases the skin’s sensitivity to UV.

Learn more: Tranexamic acid guide  ·  Found in: F-TRANEXAMIC, F-HA GLOW, F-MELACLEAR

Source: Bio-fermentation (produced from bacteria)

Oligopeptide-34. CG-TGP2 acts as a skin brightening, sun protection, anti-ageing active. It is a double layered encapsulated
biomimetic peptide which provides even skin tone, prevents photoageing and age spots. It significantly inhibits melanin synthesis on
melanocyte cell line. CG-TGP2 is designed to help even out the appearance of age spots and brown spots, and to support improvement in the look of photo-ageing and skin
tone evenness.

CG-TGP2 mimicking peptide induces degradation of MITF, inactivates the major factor for melanin-generating enzymes, tyrosinase, TRP-1, TRP-2,
which restrains the activation by alpha-MSH.
• Is designed to help inhibit melanin synthesis and tyrosinase activity.
• Is designed to help block melanosome transfer from melanocyte to keratinocyte.

Learn more: Peptides guide

Source: Natural (derived from rutin)

Has a soothing action on the skin that keeps it balanced and even toned. It appeases irritated tissue and helps to regenerate healthy skin, helping reduce the appearance of redness.

Found in: F-XBC, F-MAGISTRAL

Source: Bio-fermentation (produced from bacteria)

A multifunctional protein able to help soothe the skin and protect against photoageing caused by ROS, MMP-9 and TNFα induced by radiation.
Moreover, it can decrease the content of superficial melanin helping to even and illuminate skin tone.

Learn more: Growth factors guide  ·  Found in: F-RADIANCE, F-HA GLOW

Source: Natural

Repairing complex rich in amino acids: Acetyl tyrosine, proline both known for their redox properties; hydrolysed vegetable proteins (rich in
energy boosters like glutamine and glutamic acid) and ATP as an energy booster. Unirepair T43 accelerates the repair process in pre and post
treatments; it has a soothing action on the skin, helping reduce the appearance of redness, by providing amino acids that are precursors of DNA repairing enzymes but also
that have direct DNA redox activity.

Unirepair T43 is designed to help reduce DNA damage after UVB irradiation and help reduce the appearance of erythema over time.
Unirepair T43 is also an effective treatment to prevent UV-induced cellular DNA damage. Consequences of DNA Damage: Reduction in protein
synthesis, senescence (cell dormancy) and apoptosis (cell death), ageing (primary cause), skin cancer.

Source: Natural & bio-fermentation (produced from bacteria)

Two enzymes, lipase and hyaluronidase, combined with maltodextrins and micro-encapsulated. Maltodextrins are linear oligosaccharides
obtained from malt hydrolysis, so they can be considered biotechnological products originating from plant raw materials. Apart from the considerable
moisturising properties typical of sugar molecules, maltodextrins protect the active principle, improving the stability. In particular, the enzymes
complexed with maltodextrins maintain longer their activity once included in the finished product, which makes it possible to take the maximum
advantage of their properties.
Lipase is an enzyme acting specifically on triglyceride hydrolysis, thus reducing adipose storage. Hyaluronidase exerts its specific activity of
hydrolysis on hyaluronic acid, determining a decrease of water retention typically present in cellulite. The regular application improves skin
appearance, significantly reducing the signs of cellulite. The possible association with herbal extracts can further enhance the activity of the
product.

Found in: F-XBC

Source: Natural, extracted from rice.

Vegan ceramides are a rice extract made with a process to optimize the sphingolipid and phospholipid fraction. Ceramides play an important
role in the structure and quality of the stratum corneum. Ceramides represent the main components of the intercellular lipid cement (40%).

They control several essential biological functions:
– regulation of the trans-epidermal water flow.
– cohesion of the stratum corneum layers and protection of the skin.
– restoration of the skin barrier.

Found in: F-NIACINAMIDE, EXOSOMES SERUM, CERAMID MOISTURIZER

Source: Bio-fermentation (produced from bacteria)

Vascular Endothelial Growth Factor stimulates new blood vessel formation. VEGF, which stimulates vasculogenesis and angiogenesis, is one of
the most important proangiogenic factors in the skin. VEGF is present at high levels in cutaneous wounds, and multiple cell types, including
keratinocytes, macrophages, and fibroblasts that produce VEGF in response to injury. The importance of VEGF in the repair process is well established, especially as a proangiogenic factor. In hair growth stimulation, VEGF creates new blood vessels to improve blood supply to hair
follicles that increase nutrient feeding.

Learn more: Growth factors guide  ·  Found in: HAIR MEN MIST, F-COUPERIX, F-HAIR MEN

Source: Synthesis

Regulates the processes of differentiation, proliferation and intercellular communication. When it gets into a cell, it can make a bond with nuclear
sensors. Thus, sections of the cell genome are activated or decelerated. Retinol provides minimal skin damage, a brief recovery period and a low
probability of complications. Retinol can effectively cleanse the skin, has a soothing action on the skin, makes skin glow, improves skin texture and
structure, and provides a lifting effect.

Learn more: Retinol guide  ·  Found in: RETINOL 1.0, EYE BOOSTER, SKIN BOOSTER CREAM

Source: Synthesis (nature-identical)

Niacinamide (nicotinamide) comprises one of the two forms of Vitamin B3; niacin (or nicotinic acid) being the other, both of which provide
equivalent vitamin activity. As an essential component of living cells, Vitamin B3 is essential for protein, carbohydrate and fat metabolism.
Niacinamide is a precursor in the synthesis of the pyridine coenzymes NAD and NADP involved in cell metabolism, and as such plays a key role
in the production of energy.

Key attributes:
• Upregulates Aquaporin-3 (AQP3) (in vitro)
• Enhances skin tone (in vitro)
• Helps improve the overall appearance of skin
• Improves skin texture
• Evens skin complexion
• May help to reduce the appearance of acne
• May help to revitalize hair to minimize hair fall and improve its overall appearance

Learn more: Niacinamide guide  ·  Found in: F-NIACINAMIDE, NIACINAMIDE 5.0, GLYCOLIC B3 FOAM

Source: Synthesis (nature-identical)

DL-Panthenol is the provitamin of DL-Pantothenic acid (Vitamin B5), which plays a key role in the human intermediary metabolism. Deficiency
of Vitamin B5 can result in many dermatological disorders. DL-Panthenol is applied in almost all types of cosmetic preparations. It cares for hair, skin
and nails. It acts as a skin conditioning agent to provide deep penetrating moisture to the skin, stimulating epithelisation to provide wound healing and a soothing effect on the skin. It also functions as a hair conditioning agent to provide long-lasting moisture to hair, preventing damage,
thickening hair and improving luster and sheen. This product can also be used in nail care products to improve hydration and impart flexibility.

Found in: HAIR MEN MIST, HAIR MIST, F-ACN

Source: Synthesis (nature-identical)

Vitamin B6, also known as pyridoxine, is needed for a wide range of biological functions, including cellular metabolism, energy production and the synthesis of RNA and DNA, the instructions the epidermis relies on for its constant repair and renewal.

In the skin, vitamin B6 helps regulate hormone activity and sebum production, reducing the skin’s sensitivity to androgens such as testosterone and dihydrotestosterone. This regulating action makes it a valuable supporting active for oily and blemish-prone skin.

Source: Synthesis (nature-identical)

Because folic acid helps to facilitate the development of healthy skin cells, it can help address the visible signs of premature ageing, specifically the appearance of wrinkles and fine
lines. It has also been found to increase the production of collagen to give you firmer and more toned skin. Folic acid, also known as vitamin B9,
works like an antioxidant to promote cell turnover and fight free radical damage. When applied topically along with creatine, it is known to help address signs of sun damage and ageing, leading to firmer-looking skin.

Found in: HAIR MEN MIST, LIFT SLEEPING MASK, MESO REPAIR CREAM

Source: Synthesis (nature-identical)

Vitamin C is a very effective anti-oxidant that neutralizes free radicals – the unstable molecules that age the skin as a result of pollution, smoking

and exposure to the sun. It inhibits melanin, stimulates growth of the hydro-lipid film and enhances collagen synthesis, an important skin protein
that strengthens the structural support and elasticity of the skin.

Found in: F-VITAMIN C, VITAMIN C 5.0, VIT C MICRO-WATER

Source: Natural

Tocopherol is a form of Vitamin E typically derived from vegetable oils. Tocopherol is known as an antioxidant superhero that provides
protection for skin. (This shouldn’t be terribly surprising, since tocopherols make up 96% of skin’s natural antioxidant defence system!). Studies
show tocopherol: Absorbs UV rays and helps prevent UV-induced free radical damage to skin. Has a soothing action on the skin. Helps
moisturise. Helps reduce pollution-related free radical damage. There’s also preliminary evidence that it can help prevent scarring and reduce
the signs of ageing, too.

Found in: EYE BOOSTER, SKIN BOOSTER CREAM, RETINOL 1.0

Source: Synthesis (nature-identical)

Biotin, also known as vitamin B7, is a water-soluble, B-complex vitamin that contributes to healthy metabolic, nerve, digestive and cardiovascular
functions. It is essential for metabolising fats and carbohydrates and works synergistically with pantothenic acid (vitamin B5) to strengthen hair,
increase nail thickness and prevent split ends and thinning hair. It assists in the production of new cells and helps oil glands function properly,
resulting in the healthy condition of skin.

Found in: F-HAIR

Source: Natural (mineral)

Zinc is an essential trace element involved in more than 300 enzymatic reactions in the body. In the skin, it supports wound healing and barrier repair, helps regulate the activity of the sebaceous glands and has recognized soothing properties, which is why it is widely used in formulas for oily, blemish-prone or irritated skin.

Zinc also plays an important role in hair tissue growth and repair: it contributes to DNA and RNA production, required for the normal division of hair follicle cells, keeps the oil glands around the follicles working properly and helps maintain balanced hormone levels, one of the reasons it is valued in the prevention of hair thinning.

Found in: HAIR MEN MIST, HAIR MIST, F-ACN