What is PDRN?

PDRN (polydeoxyribonucleotide) is a purified DNA fraction, traditionally obtained from salmon DNA, whose polynucleotide chains are recognised by the skin as building blocks for repair. First used in regenerative and wound-care medicine, PDRN has become one of the most sought-after actives in aesthetic medicine, where it is prized for its ability to support tissue regeneration, improve skin elasticity and calm post-procedure inflammation.

Why PDRN matters in aesthetic medicine

Practitioners value PDRN for three well-documented properties:

• Regeneration – polynucleotides provide the substrates skin cells need to rebuild, supporting fibroblast activity and collagen synthesis.
• Soothing – PDRN modulates the inflammatory response, which is why it is so often used after aggressive procedures such as laser, peels or micro-needling.
• Hydration and elasticity – clinical experience shows visible improvement in skin quality, texture and bounce.

How professionals use PDRN with treatments

PDRN-based skincare is designed to complement in-clinic protocols: applied after micro-needling or mesotherapy sessions to support recovery, and prescribed as home care between sessions to extend and consolidate results. This clinic-plus-homecare approach is central to the Fusion Meso philosophy.

Fusion Meso formulations with PDRN

• EYE BOOSTER – regenerative eye contour treatment combining PDRN with biotechnological actives for eye bags, dark circles and fine lines.
• SKIN BOOSTER CREAM – advanced cellular regeneration cream with PDRN, exosomes and retinol, ideal for post-procedure repair and anti-ageing maintenance.

Frequently asked questions

Is topical PDRN the same as injectable polynucleotides?

No. Injectable polynucleotides are medical devices administered by practitioners. Topical PDRN skincare works at the skin surface and is designed to complement professional treatments and maintain their results at home.

Can PDRN skincare be used after micro-needling?

Yes – post-procedure application is one of its main indications, always following the protocol recommended by your practitioner.

Who should recommend PDRN skincare?

Fusion Meso products are developed for aesthetic professionals and clinics, who recommend them to patients as part of a complete treatment plan.