What is tranexamic acid?

Tranexamic acid (TXA) started life as a medicine before dermatology discovered its remarkable effect on pigmentation. Rather than bleaching pigment that has already formed, TXA interrupts the conversation between melanocytes and their environment – calming the inflammatory and vascular signals that drive melasma and post-inflammatory hyperpigmentation (PIH).

How it works

• Melanogenesis control – reduces melanocyte-keratinocyte interaction and promotes degradation of MITF, the master pigmentation switch.
• Vascular and anti-inflammatory action – unique among brighteners, TXA also addresses the redness and vascular component of melasma.
• Documented in mesotherapy – intradermal tranexamic microinjections significantly reduced MASI melasma scores at 8 and 12 weeks in published studies, without notable side effects.

Fusion Meso formulations with tranexamic acid

• F-TRANEXAMIC – tranexamic acid sterile vials, the dedicated pigmentation protocol.
• F-MELACLEAR – TXA combined with niacinamide, resorcinol, glutathione and arbutin for localised dark spots.
• F-HA GLOW – hyaluronic skin booster with TXA and brightening peptide for global radiance.
• MELA DROPS – intensive home-care booster: TXA with hexylresorcinol, glycolic acid and niacinamide.
• GLOW SLEEPING MASK – overnight brightening with TXA and niacinamide.

Protocol notes for professionals

Tranexamic protocols are evaluated over 8-12 weeks and always paired with daily SPF50 – Fusion Meso MESO SHIELD 50 completes the routine. In-clinic vials address the pigment at its source; home boosters maintain the result between sessions.

Frequently asked questions

Is tranexamic acid suitable for all skin types?

Its non-aggressive mechanism makes it one of the best-tolerated pigmentation actives, including for darker phototypes prone to PIH – under professional guidance.

TXA or hydroquinone?

Published comparisons show topical TXA performing comparably to hydroquinone-based regimens on melasma, with a far gentler profile – which is why it has become the modern first-line choice.