DMAE or Norcholine started to be used in external products to produce a lifting effect. It is a natural compound in our body. DMAE is a precursor of acetylcholine, a neuro-mediator which plays an important role in the skin. Keratinocytes, fibroblasts, myofibroblasts, sweat cells and endothelial cells, have membrane receptors and respond to acetylcholine. The tensile effect of DMAE results in a cholinergic stimulation of membrane receptors of fibroblasts and stimulates progressive concentration of the myofilaments of its cytosol. DMAE also has anti radical and anti lipofuscine activities and it repairs the protein cross linking (collagen and elastin). The mode of action of DMAE can consequently result a synergistic combination of actions at different levels: tension of dermal non-muscle cells, cohesion and displacement of keratinocytes, hydration and elasticity of the stratum corneum, better nutrition and skin defences, free radical scavenger. Immediate and long-lasting effect. Note that DMAE cannot be combined with botox and F-BTX treatments.